![]() ![]() ![]() In this review, we will discuss the key role played by α2AP in controlling thrombosis and fibrinolysis and, we will consider its potential value as a therapeutic target in cardiovascular diseases and ischemic stroke.Īlpha2-Antiplasmin (α2AP) is the Serpin That Kills Plasmin Recent studies also show that α2AP is required for the development of stasis thrombosis by inhibiting the early activation of effective fibrinolysis. Through these mechanisms and others, α2AP contributes to brain injury, hemorrhage and swelling in experimental ischemic stroke. In addition, α2AP fosters the development of microvascular thrombosis and enhances matrix metalloproteinase-9 expression. Mechanistic studies in disease models indicate that α2AP stops the body's own fibrinolytic system from dissolving pathologic thrombi that cause venous thrombosis, pulmonary embolism, arterial thrombosis, and ischemic stroke. ![]() Epidemiology studies have shown an association between high α2AP levels and increased risk or poor outcome in cardiovascular diseases. However, studies of humans and mice with genetic deficiency of α2AP have expanded our understanding of this serpin, particularly in disease states. Department of Medicine, University of Arizona-College of Medicine, Phoenix, AZ, United StatesĪlpha2-antiplasmin (α2AP), the fast-reacting, serine protease inhibitor (serpin) of plasmin, was originally thought to play a key role in protection against uncontrolled, plasmin-mediated proteolysis of coagulation factors and other molecules.Roll of Successful Examinees in the SPECIAL PROFESSIONAL LICENSURE EXAMINATION FOR ARCHITECTS Held on APRIL 22 & 23, 2023 Page: 3 of 4 Released on JSeq. N a m e 1 ABAD, DAN DAVIES CABANGCALA 2 ABINALES, SHANN MEIA JOLLIENE CAPARAZ 3 ABOC, JERUEL FAJARDO 4 ACDAL, LUCKY ANGELA TORIBIO 5 ACEBEDO, APRIL DAGSAN 6 ACEJAS, SALVADOR IV BUMBAY 7 ACOSTA, ANGELITO PARALLAG 8 AGARIN, CEILO GONZALES 9 AGUIRRE, JOSE ANTONIO IBARBIA 10 ALABA, ROGELIO JR ANGELES 11 AMOYO, STEPHEN ANGELO ESPIRITU 12 APIL, LESER JUN VILLAGRACIA 13 ARATAN, ANNGELA 14 AVILES, CAROLINE MANGUBAT 15 AYSON, KEVIN KIT SAGUN 16 BALALLO, KRYSTEL JOYCE QUERUBIN 17 BALINOS, MIKKO GERALD MAGSOMBOL 18 BALLA, LOUIE ABAD 19 BARAL, JOHN CARLO ANGA 20 BARCENILLA, ROBBY TINGSON 21 BAROMAN, CRISANTO JR VILLAFLOR 22 BATACAN, MARI CONRAD QUINTANA 23 BELARMA, ANDREA ROSE GAMEZ 24 BERMEJO, BARRY BADOY 25 BORINGOT, JOHN ALDWIN CASIM 26 BUENCONSEJO, JOSELITO MATIBAG 27 BUMATAY, BERLYN ANNE AGUIRRE 28 CABALUNA, REGIE CASTILLA 29 CADAG, ALISSANDRA JASMINE LABASANO 30 CAGUETE, ZALDY CASTILLO 31 CARIAGA, MELVIN BRIAN INLONG 32 CASTRO, NEIL SALAZAR 33 CERVANTES, RAFAEL ERIC CORTEZANO 34 CO, ROMMEL BELGICA 35 CONDEMILICOR, GLENN FIGUERAS 36 DE GUZMAN, DAVE IVAN TULLAO 37 DE LEON, JISELLE KEANNE SIBAYAN 38 DELA TORRE, MARY YASMIN JACOSALEM 39 DOMINGO, IRENE VAN ROSE MATEO 40 ECHEVARRIA, ARNEL CATAPIA 41 ELEPANIO, VICTOR PAOLO CUBANGBANG 42 ELLOSCA, WINSTON SELGA 43 ENCARNACION, ARNEL MARTINEZ 44 ESQUILLO, STELLA MARIE ARPON 45 EVA, ERIC MANANGUITE 46 FACTOR, GILBERT MOGRO 47 FAJARDO, JEMUEL DELA CRUZ 48 FAUSTINO, JOSEPH VERGARA 49 FELIZARIO, NORLYN CLARIZ GARCIA 50 FRANCISCO, JENNIFER PANTALEON Roll of Successful Examinees in the SPECIAL PROFESSIONAL LICENSURE EXAMINATION FOR ARCHITECTS Held on APRIL 22 & 23, 2023 Page: 2 of 4 Released on JSeq.
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